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Effects of bee venom on the pro-inflammatory responses in RAW264.7 macrophage cell line
새창
Abstract The purpose of this study is to elucidate the molecular mechanism of anti-inflammatory effect of bee venom (BV), which has been used for the treatment of various inflammatory diseases in oriental medicine. With this aim, we examined the effects of BV on the nitric oxide (NO) production by …
최고관리자 2014-12-16 15:17:51 -
Effects of Yukmijihwang-tang derivatives (YMJd), a memory enhancing herbal extract, on the gene-expression profile in the rat hippocampus
새창
Abstract The herbal extract Yukmijihwang-tang (YMJ) has been widely used for centuries as an anti-aging herbal medicine in Asian countries. Among the various modified prescriptions of YMJ, YMJ derivatives (YMJd) were formulated to enhance memory retention. This study has three goals: 1) to quantita…
최고관리자 2014-12-16 14:09:32 -
Enhancement of electroacupuncture-induced analgesic effect in cholecystokinin-A receptor deficient rats
새창
Abstract Previously, we have showed that the cholecystokinin (CCK)-A receptor expression in hypothalamus is closely related with the responsiveness of electroacupuncture (EA)-mediated analgesic effects in rats. In order to confirm this observation more directly in vivo, the EA-mediated analgesic ef…
최고관리자 2014-12-16 14:01:24 -
The association of cholecystokinin-A receptor expression with the responsiveness of electroacupuncture analgesic effects in rat
새창
Abstract The purpose of this study is to determine whether the level of cholecystokinin (CCK) receptor expression causes the differences between the responder and non-responder to electroacupuncture mediated analgesic effects. Male Sprague-Dawley rats were stimulated at the Zusanli (ST36) acupoint …
최고관리자 2014-12-16 13:09:02 -
Molecular basis for interactions of G protein βΓ subunits with effectors
새창
Abstract Both the α and βΓ subunits of heterotrimeric guanine nucleotide- binding proteins (G proteins) communicate signals from receptors to effectors. GβΓ subunits can regulate a diverse array of effectors, including ion channels and enzymes. Gα subunits bound to guanine diphosphate (Gα-GDP) inhi…
최고관리자 2014-12-16 12:53:29 -
Mapping of effector binding sites of transducin α-subunit using Gαt/Gαi1 chimeras
새창
Abstract The G protein transducin has been an often-used model for biochemical, structural, and mechanistic studies of G protein function. Experimental studies have been limited, however, by the inability to express quantities of mutants in heterologous systems with ease. In this study we have made…
최고관리자 2014-12-16 12:46:44