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Regulation of the 5-HT3A receptor-mediated current by alkyl 4-hydroxybenzoates isolated from the seeds of Nelumbo nucifera
새창
Abstract Four known alkyl 4-hydroxybenzoates, i.e., methyl 4-hydroxybenzoate (1), ethyl 4-hydroxybenzoate (2), propyl 4-hydroxybenzoate (3), and butyl 4-hydroxybenzoate (4), were isolated from the seeds of Nelumbo nucifera GAERTNER (Nymphaeaceae) for the first time. The structures of the isolates w…
최고관리자 2014-12-16 21:03:55 -
Effects of protostane-type triterpenoids on the 5-HT3A receptor-mediated ion current in Xenopus oocytes
새창
Abstract Alisol derivatives are unique protostane-type triterpenoid compounds that are isolated from Alismatis rhizoma, which is a well-known traditional medicine in East Asia. In the present study, we investigated the effects of protostane-type triterpenoids (AA, Alisol A; AB, Alisol B; AB-ac, Ali…
최고관리자 2014-12-16 20:18:28 -
Inhibition effects of Vitex rotundifolia on inflammatory gene expression in A549 human epithelial cells
새창
Abstract Background: Vitex rotundifolia has long been used in traditional medicine to treat asthma and other allergic diseases. Objective: To evaluate the anti-inflammatory mechanisms of V rotundifolia in cultured A549 human alveolar epithelial cells. Methods: In the present study, A549 cells were …
최고관리자 2014-12-16 19:08:56 -
Global gene analysis of erigeron canadensis-treated TNF-α-, IL-4- and IL-1β-stimulated A549 human epithelial cells
새창
Abstract Background/Aims: This study was conducted to evaluate the anti-inflammatory mechanisms of Erigeron canadensis (EC) on the tumor necrosis factor-α (TNF-α)-, interleukin (IL)-4- and IL-1β-induced stimulation of A549 cells. Methods: In the present study, the anti-inflammatory effects of EC on…
최고관리자 2014-12-16 19:07:29 -
Genetic association between 5′-upstream single-nucleotide polymorphisms of PDGFRB and schizophrenia in a Korean population
새창
Abstract PDGFRB is located on chromosome 5q31-q32, a chromosomal region identified by linkage analyses to contain a susceptibility gene for schizophrenia (SCZ). Recent research has focused on the role of the N-methyl-d-aspartate (NMDA) receptor in the pathogenesis of SCZ. D4 dopamine receptor-media…
최고관리자 2014-12-16 18:23:18 -
Inhibition effects of Moutan Cortex Radicis on secretion of eotaxin in A549 human epithelial cells and eosinophil migration
새창
Abstract Eosinophils have been implicated in a broad range of diseases, most notably allergic conditions (e.g. asthma, rhinitis and atopic dermatitis) and inflammatory diseases. These diseases are characterized by an accumulation of eosinophils in the tissue. Defining the mechanisms that control eo…
최고관리자 2014-12-16 17:28:51 -
Nelumbinis Semen reverses a decrease in hippocampal 5-HT release induced by chronic mild stress in rats
새창
Abstract Depression is associated with a dysfunctional serotonin system. Recently, several lines of evidence have suggested that a very important evoking factor in depression may be a serotonin deficit in the hippocampus. This study assessed the antidepression effects of Nelumbinis Semen (NS) throu…
최고관리자 2014-12-16 14:39:26 -
Two amino acids within the helix of Gα(i1) mediate coupling with 5- hydroxytryptamine(1B) receptors
새창
Abstract We previously reported that residues 299-318 in Gα(i1) participate in the selective interaction between Gα(i1) and the 5-hydroxytryptamine(1B) (5- HT(1B)) receptor (Bae, H., Anderson, K., Flood, L. A., Skiba, N. P., Hamm, H. E., and Graber, S. G. (1997) J. Biol. Chem. 272, 32071-32077). Th…
최고관리자 2014-12-16 12:59:04 -
Molecular determinants of selectivity in 5-hydroxytryptamine(1B) receptor-G protein interactions
새창
Abstract The recognition between G protein and cognate receptor plays a key role in specific cellular responses to environmental stimuli. Here we explore specificity in receptor-G protein coupling by taking advantage of the ability of the 5-hydroxytryptamine(1B) (5-HT(1B)) receptor to discriminate …
최고관리자 2014-12-16 12:49:35