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Bee venom mitigates cisplatin-induced nephrotoxicity by regulating CD4 +CD25+Foxp3+ regulatory T cells in mice
새창
Abstract Cisplatin is used as a potent anticancer drug, but it often causes nephrotoxicity. Bee venom (BV) has been used for the treatment of various inflammatory diseases, and its renoprotective action was shown in NZB/W mice. However, little is known about whether BV has beneficial effects on cis…
최고관리자 2014-12-17 00:06:37 -
Bee venom attenuates experimental autoimmune encephalomyelitis through direct effets on CD4+CD25+FOXP3+ T cells
새창
Abstract Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that leads to substantial disability through deficits of sensation and of motor, autonomic, and neuro-cognitive function. Many clinical and pathological features of experimental autoimmune encephalomyel…
최고관리자 2014-12-17 00:00:19 -
Cd4+cd25+ regulatory t cell depletion modulates anxiety and depression-like behaviors in mice
새창
Abstract Stress has been shown to suppress immune function and increase susceptibility to inflammatory disease and psychiatric disease. CD4+CD25+ regulatory T (Treg) cells are prominent in immune regulation. This study was conducted to determine if anti-CD25 antibody (Ab) mediated depletion of Treg…
최고관리자 2014-12-16 23:49:23 -
Herbal formula, PM014, attenuates lung inflammation in a murine model of chronic obstructive pulmonary disease
새창
Abstract Chronic obstructive pulmonary disease (COPD), which is characterized by airway obstruction, leads to, as the two major forms of COPD, chronic bronchitis and emphysema. This study was conducted to evaluate the effects of herbal formula, PM014, in a murine model of COPD. Balb/c mice were tre…
최고관리자 2014-12-16 23:47:33 -
Electroacupuncture attenuates ovalbumin-induced allergic asthma via modulating CD4 +CD25 + regulatory T cells
새창
Abstract A mouse pulmonary hypersensitivity experimental model that mimics human asthma was developed, and electroacupuncture (EA) treatment was shown to reduce allergic inflammatory processes. In addition, we also assessed whether the beneficial effects of EA on allergic asthma could be correlated…
최고관리자 2014-12-16 23:43:38 -
The genome-wide expression profile of 1,2,3,4,6-penta-O-galloyl-ß-D- glucose-treated MDA-MB-231 breast cancer cells: Molecular target on cancer metabolism
새창
Abstract 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a polyphenolic compound isolated from Rhus chinensis Mill. PGG has been known to have anti-tumor, anti-angiogenic and anti-diabetic activities. The present study revealed another underlying molecular target of PGG in MDA-MB-231 breast cancer …
최고관리자 2014-12-16 21:27:49 -
Inhibitory effects of casticin on migration of eosinophil and expression of chemokines and adhesion molecules in A549 lung epithelial cells via NF-κB inactivation
새창
Abstract Ethnopharmacological relevance: The fruits of Vitex rotundifolia L. have long been used for the treatment of inflammation of the respiratory tract in East Asia. Aim: To determine if casticin, one of the constituents of Vitex rotundifolia L., has anti-allergic and anti-inflammatory effects …
최고관리자 2014-12-16 21:24:24 -
1,2,3,4,6-Penta-O-galloyl-beta-D-glucose reduces renal crystallization and oxidative stress in a hyperoxaluric rat model
새창
Abstract Adhesion of calcium oxalate (CaOx) crystals to kidney cells may be a key event in the pathogenesis of kidney stones associated with marked hyperoxaluria. Previously, we found that 1,2,3,4,6-penta-O-galloyl-Β-D-glucose (PGG), isolated from a traditional medicinal herb, reduced CaOx crystal …
최고관리자 2014-12-16 21:18:34 -
Inhibitory effect of Platycodon grandiflorum on TH1 and T H2 immune responses in a murine model of 2,4-dinitrofluorobenzene- induced atopic dermatitis-like skin lesions
새창
Abstract Background: Platycodon grandiflorum is a traditional Asian medicine that is used to treat pulmonary and respiratory allergic disorders. Objective: To investigate the effects of P grandiflorum in vivo in an animal model of atopic dermatitis (AD), with particular emphasis on its effects on T…
최고관리자 2014-12-16 21:15:16 -
CD4+ CD25+ regulatory T cells attenuate cisplatin-induced nephrotoxicity in mice
새창
Abstract Nephrotoxicity limits the use of cisplatin, a widely used chemotherapeutic agent for treatment of various malignancies. Overall, CD4+ T cells mediate cisplatin-induced renal injury; however, the CD4+ CD25 + regulatory T-cell subset (CD4+ CD25+ Treg) has broad suppressive effects on many di…
최고관리자 2014-12-16 21:14:17