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기타논문 게시판 내 결과
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Pyranopyran-1,8-dione, an Active Compound from Vitices Fructus, Attenuates Cigarette-Smoke Induced Lung Inflammation in Mice
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1. Introduction During the last twenty years, new anti-inflammatory drugs are being discovered and developed as anti-cytokine agents with the massive expansion of the study on inflammatory response [1,2]. People, however, still long for cheaper and more effective alternative approaches to treat …
최고관리자 2017-07-26 08:49:25 -
Treatment with pyranopyran-1, 8-dione attenuates airway responses in cockroach allergen sensitized asthma in mice
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Abstract Chronic allergic asthma is characterized by Th2-typed inflammation, and contributes to airway remodeling and the deterioration of lung function. Viticis Fructus (VF) has long been used in China and Korea as a traditional herbal remedy for treating various inflammatory diseases. Previously,…
최고관리자 2014-12-17 01:13:32 -
A synthetic compound, 4-acetyl-3-methyl-6-(3,4,5-trimethoxyphenyl)pyrano[3, 4-c]pyran-1,8-dione, ameliorates ovalbumin-induced asthma
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Abstract Eosinophilia is one of the characteristic signs of allergic inflammation. Massive migration of eosinophils to the airways can cause epithelial tissue injury, contraction of airway smooth muscle and increased bronchial responsiveness. Previously, we discovered a new compound, 1H,8H-pyrano[3…
최고관리자 2014-12-17 00:32:55 -
A novel synthetic compound 4-Acetyl-3-methyl-6-(2-bromophenyl)pyrano[3,4-c] pyran-1,8-dione inhibits the production of nitric oxide and proinflammatory cytokines Via the NF-κB pathway in lipopolysaccharide-activated microglia cells
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Abstract Previously, we discovered a new compound, 1H,8H-Pyrano[3,4-c]pyran-1,8- dione (PPY), from Vitex rotundifolia L. and evaluated its anti-inflammatory and anti-asthmatic effects. In this study, we synthesized a new, modified compound 4-acetyl-3-methyl-6-(2-bromophenyl)pyrano[3,4-c]pyran-1,8-d…
최고관리자 2014-12-17 00:08:17 -
Compound K inhibits basic fibroblast growth factor-induced angiogenesis via regulation of p38 mitogen activated protein kinase and AKT in human umbilical vein endothelial cells
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Abstract Compound K (CK; 20-0-β-D-glucopyranosyl-20(5)-protopanaxadiol), an active ginseng saponin metabolite, exerts anticancer activity via apoptosis induction in various cancers. In the present study, we investigated the anti-angiogenic activity of CK and its molecular mechanisms in human umbili…
최고관리자 2014-12-16 20:20:59 -
A new compound, 1H,8H-Pyrano[3,4-c]pyran-1,8-dione, suppresses airway epithelial cell inflammatory responses in a murine model of asthma
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Abstract Clinical and experimental studies have established eosinophilia as a sign of allergic disorders. Activation of eosinophils in the airways is believed to cause epithelial tissue injury, contraction of airway smooth muscle and increased bronchial responsiveness. As part of the search for new…
최고관리자 2014-12-16 19:01:29 -
The genome-wide expression profile of Scrophularia ningpoensis-treated thapsigargin-stimulated U-87MG cells
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Abstract The endoplasmic reticulum (ER) is a principal site for protein synthesis, protein folding, calcium storage, and calcium signaling. Thapsigargin (TG), an inducer of ER stress, inhibits ER-associated Ca2+-ATPase and disrupts Ca2+ homeostasis. ER stress plays an important pathogenetic role in…
최고관리자 2014-12-16 18:54:31
뉴스 게시판 내 결과
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항- GRP78 항체의 항암 효과
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소포체(endoplasmic reticulum, ER)에서 쉐퍼론(chaperone)의 역할을 하는 GRP78은 종양 표면으로 이동하여 암의 성장과 전이 및 치료에 대한 저항성을 촉진시킨다. 세포 표면에서 GRP78의 암 형성 기능은 phosphoinositide 3-kinase (PI3K) 경로의 활성화에 대한 기여를 통해 이루어진다. 미국 남가주 대학 의대 (University of Southern California Keck School of Medicine)의 파카쉬 길 (Parkash S. Gill) 교수 연구팀은 새로운 …
최고관리자 2013-10-07 16:48:37
BRIC Report 게시판 내 결과
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Autophagy 키워드 분석 (2008년 ~ 2012년)
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분 석 툴 : KOBIC Mr.Q Report (http://mrqreport.kobic.re.kr/) 분 석 기 획 : 이강수, 박지민 &n…
최고관리자 2013-10-21 08:44:20 -
Stem Cell 키워드 분석 (2008년 ~ 2012년)
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분 석 툴 : KOBIC Mr.Q Report (http://mrqreport.kobic.re.kr/) 분 석 기 획 : 이강수, 박지민 &nbs…
최고관리자 2013-09-23 11:12:51